Antibacterial and Anti-HIV-1 GP120 Activities of Selected Medicinal Plants

Authors

Rose J. Masalu, University of Dar es Salaam, TanzaniaFollow
Cyprian B. Mpinda, University of Dar es Salaam, TanzaniaFollow

Abstract

Medicinal plants play an important role in traditional medicine and drug development research because of their numerous bioactivities. However, some concerns have risen on the inefficiencies of such products due to improper use of medicinal plant products, notably when mixed with other traditional remedies. This study evaluates the antibacterial and anti-human immunodeficiency virus 1 glycoprotein 120/CD4 (anti-HIV-1 GP120/CD4) activities of medicinal plants species Sapium ellipticum, Pseudospondias microcarpa, and Capparis erythrocarpos; and their respective combinations effects. Results revealed that aqueous and ethyl acetate extracts of S. ellipticum and P. microcarpa had antimicrobial activities against S. aureus (ATCC 25923), E. coli (ATCC 25922), and K. pneumoniae (ATCC 25922); with MIC ranging from 0.31 to 100 mg mL-1. No antibacterial activity was observed for both aqueous and ethyl acetate extracts of C. erythrocarpos. An evaluation of the possible interaction with antibacterial activities of aqueous and ethyl acetate crude extracts of S. ellipticum and P. microcarpa revealed no synergic nor antagonistic interaction among them. Furthermore, the study revealed that extracts from all the three plant species and their respective combinations had potential anti-HIV-1 by inhibition on HIV-1 GP120 interactions with CD4 receptors. The evaluation of the inhibition of the extracts combinations against HIV-1 GP120 interaction to CD4 receptors revealed no significant synergic or antagonistic interactions statistically. The results from this study provide scientific information towards appropriate utilization of the plant species in traditional medicine and drug discovery.

Recommended Citation

J. Masalu, Rose and B. Mpinda, Cyprian (2022) "Antibacterial and Anti-HIV-1 GP120 Activities of Selected Medicinal Plants," Journal of Humanities and Social Sciences: Vol. 10 : No. 5 , Article 6.
Available at: https://doi.org/10.56279/jhss.v10.i5.5

Publication Date

3-10-2022

DOI

10.56279/jhss.v10.i5.5

Publisher

Dar es Salaam University College of Education (DUCE)