Evaluation of the Modulatory Effects of Capsicum Chinensis Methanol Extract in Streptozotocin-Induced Diabetic Neuropathic Pain in Mice

Authors

Babatunde A. Alabi, Department of Pharmacology and Therapeutics, Faculty of Basic Clinical Sciences, Bowen University College of Medicine, Bowen University, Osun State, Nigeria.Follow
Adeyinka Aderonmu, Neuropharmacology and Cardiovascular Units, Department of Pharmacology and Therapeutics, College of Medicine, University of Ibadan, Ibadan.Follow
Sodiq K. Lawal, School of Nursing, Faculty of Health Sciences, University of Botswana, Gaborone, BotswanaFollow
Okot-Asi T. Nku-Ekpang, Department of Physiology, Faculty of Basic Medical Sciences, University of Calabar, Cross River State, NigeriaFollow
Mayowa Ajayi, Neuropharmacology and Cardiovascular Units, Department of Pharmacology and Therapeutics, College of Medicine, University of Ibadan, Ibadan.Follow
Olugbenga E. Iwalewa, Neuropharmacology and Cardiovascular Units, Department of Pharmacology and Therapeutics, College of Medicine, University of Ibadan, Ibadan.Follow

Section

Biological Sciences

Abstract

Diabetes is one of the common causes of neuropathic pain. The first-line treatment drugs used in alleviating neuropathic pain can cause adverse effects. Therefore, the aim of this study is to evaluate the analgesic property of Capsicum chinensis, since the plant was reported to be used against chronic pain in traditional medicine. Streptozotocin-induced diabetes was adopted to model neuropathy in mice and the antihyperalgesic effect of the extract was evaluated using a hot plate test, cold allodynia test, and Randall- Selitto paw pressure test. The plasma level of pain-associated inflammatory biomarkers like interleukin-6 (IL-6) and tissue necrotic factor-α (TNF-α) was also measured. Treatment with varying doses of extract (1, 2.5, and 5 mg/kg) significantly (p < 0.05) increased the mean reaction time to thermal pain during hot and cold plate tests. During the Paw pressure test, reaction time was significantly prolonged in the treatment groups and the plasma level of TNF-α and IL-6 were reduced (p < 0.05). The extract showed a better antihyperalgesic effect than the positive control drug (gabapentin). The result obtained showed that Capsicum chinensis extract can alleviate diabetes neuropathic pain in mice models with a better analgesic effect thanthe control drug (gabapentin).

Recommended Citation

Alabi, Babatunde A.; Aderonmu, Adeyinka; Lawal, Sodiq K.; Nku-Ekpang, Okot-Asi T.; Ajayi, Mayowa; and Iwalewa, Olugbenga E. (2024) "Evaluation of the Modulatory Effects of Capsicum Chinensis Methanol Extract in Streptozotocin-Induced Diabetic Neuropathic Pain in Mice," Tanzania Journal of Science: Vol. 49: Iss. 5, Article 1.
Available at:https://doi.org/10.4314/tjs.v49i5.1