Antibacterial activities of constituents from Isolona cauliflora and Cleistochlamys kirkii

Authors

AC Odebode, Department of Botany, University of Dar es Salaam, P.O. Box 35060 Dar es Salaam, TanzaniaFollow
SJM Mdachi, Chemistry Department, University of Dar es Salaam, P.O Box 35061, Dar es Salaam, TanzaniaFollow
CC Joseph, Chemistry Department, University of Dar es Salaam, P.O Box 35061, Dar es Salaam, TanzaniaFollow
BN Irungu, Chemistry Department, University of Dar es Salaam, P.O Box 35061, Dar es Salaam, TanzaniaFollow

Section

Biological Sciences

Abstract

Antibacterial activities of caulindole D, a mixture of caulindole E and F, pinocembrin and an oxyheptanoid (cleistenolide), obtained from stem barks of Isolona cauliflora and Cleistochlamys kirkii, on Staphylococcus aureus and Pseudomonas phaseolicola were determined. An in vitro assay test by paper disc method showed that the caulindole D, E and F from Isolona cauliflora produced no inhibition zone on both bacteria pathogens at 100-200 ppm while cleistochlamic acid from C. kirkii showed weak to moderate inhibition zone at 100-200 ppm. At concentration above 200 ppm, the bacteria pathogens were inhibited by all the compounds isolated from the plant extracts. Furthermore, there was an influence of bioassay method on the sensitivity of extracts on both test bacteria.

Recommended Citation

Odebode, AC; Mdachi, SJM; Joseph, CC; and Irungu, BN (2003) "Antibacterial activities of constituents from Isolona cauliflora and Cleistochlamys kirkii," Tanzania Journal of Science: Vol. 29: Iss. 2, Article 3.
Available at:https://doi.org/10.65085/2507-7961.2049