Synthesis of bis-(3-carbethoxy-6-methoxy-4-methyl-2-quinolyl) selenide

RR Malisa, Department of Chemistry, University of Dar es Salaam, P.O. Box 35061, Dar es Salaam, TanzaniaFollow
G L. Mhehe, Department of Chemistry, University of Dar es Salaam, P.O. Box 35061, Dar es Salaam, TanzaniaFollow
SJM Mdachi, Department of Chemistry, University of Dar es Salaam, P.O. Box 35061, Dar es Salaam, TanzaniaFollow

Section

Physical Sciences

Abstract

In the execution of a synthetic strategy aiming at 3-acetyl-2,4-dichloro-6-methoxyquinoline, a precursor to a 4-methoyselenolo[2,3-b]quinolone, we have instead obtained 2-chloro-3-carbethoxy-6-methoxy-4-methylquinoline. These results strongly suggest that the compound claimed to be 3-acetyl-2,4-dihydroxy-6-methoxyquinoline in the literature and a precursor to 3-actyl-2,4-dichloro-6-methoxyquinoline, is 3-carbethoxy-2-hydroxy-6-methoxy-4-methylquinoline, a precursor to 2-chlo-3-carbethoy-6-methoxy-4-methylquinoline. The reaction of the latter compound with sodium hydrogen selenide in ethanol yielded bis-(3-carbethoxy-6-methoxy-4-methyl-2-quinolyl) selenide.

Recommended Citation

Malisa, RR; Mhehe, G L.; and Mdachi, SJM (1999) "Synthesis of bis-(3-carbethoxy-6-methoxy-4-methyl-2-quinolyl) selenide," Tanzania Journal of Science: Vol. 25: Iss. 1, Article 6.
Available at:https://doi.org/10.65085/2507-7961.2388